The authors examined clinical data from more than 10,000 children with cancer and the same number of healthy children. First, they tried to find out whether children of older fathers had a higher risk of retinoblastoma, an eye cancer that originates from a genetic mutation in the father’s sperm. But the results were inconclusive. It seems that children of fathers over 45 years of age have a higher risk of this cancer, but the differences were not statistically significant.
However, a second analysis of the data revealed that the risk of ALL is significantly higher among children of older fathers and mothers. The risk begins to increase if the mother is in her thirties and the father is over 40 years old, and increases proportionally to the age of the parents.
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