JAMA - 07/23/03
Volume 290, Number 4
Breast Cancer Fo=llowing Radiotherapy and Chemotherapy Among Young Women With Hodgkin Disease Lois B. Travis; Deirdre A. Hill; Graça M. Dores; Mary Gospodarowicz; Flora E. van Leeuwen; Eric Holowaty; Bengt Glimelius; Michael Andersson; Tom Wiklund; Charles F. Lynch; Mars B. Vant Veer; Ingrid Glimelius; Hans Storm; Eero Pukkala; Marilyn Stovall; Rochelle Curtis; John D. Boice, Jr; Ethel Gilbert
Section : Original Contributions
Areas of interest : Clinical hematology. E. Hodgkin. Clinical research. Hematology and Hemotherapy. Obstetrics and Gynecology. Oncology. Senology.
In this case-control study, the risk of suffering from breast cancer was analyzed among 3,187 women under 30 years of age diagnosed with Hodgkin lymphoma in relation to the radiation dose received by the breast and the cycles of alkylating agents administered. The relative risk of a dose of 4 grays or more to the breast was 3.2 times greater than that observed in patients who received a lower dose and no alkylating agent. The risk increased up to 8 times when radiation doses were greater than 40 grays. However, when the patient was treated only with alkylating agents, the risk decreased by 40%. The authors conclude that young women with Hodgkin lymphoma who have been treated with radiotherapy alone appear to have an increased risk of developing breast cancer.
Effects of a Dietary Portfolio of Cholesterol-Lowering Foods vs Lovastatin on Serum Lipids and C-Reactive Protein David JA Jenkins; Cyril W. C. Kendall; Augustine Marchie; Dorothea A. Faulkner; Julia MW Wong; Russell de Souza; Azadeh Emam; Tina L. Parker; Edward Vidgen; Karen G. Lapsley; Elke A. Trautwein; Robert G. Josse; Lawrence A. Leiter; Philip W. Connelly
Section : Clinical Investigation
Areas of interest :
In this clinical trial patients were randomly assigned to one of the following three diets: a first very low in saturated fat, based on ground whole grain cereals and with low-fat dairy products , which served as a control; the second was the same as the first plus a lovastatin dose of 20 mg7day; and the third was a diet rich in plant sterols, soy proteins, viscous fibers and almonds. lipid and Creactive protein levels
Breast Cancer After Hodgkin Disease: Hope for a Safer Cure Joachim Yahalom
Section : Editorials
Areas of interest : Hematology and Hemotherapy. Obstetrics and Gynecology. Oncology. Senology.
This editorial accompanies a study in which the authors conclude that young women with Hodgkin lymphoma who have been treated with radiotherapy alone appear to have an increased risk of developing breast cancer. The editorialist comments that the study data reinforce the idea that the use of short-term chemotherapy and low doses of radiation can offer a safer cure.
